Nicolas Buchler joined NC State in July 2018 as a Chancellor’s Faculty Excellence Program cluster hire in Modeling the Living Embryo. Buchler, an associate professor in the Department of Molecular Biomedical Sciences, focuses his research on understanding how the cell cycle interacts with metabolic rhythms, and how changes in these interactions lead to disease or new functions. Buchler’s lab primarily works with early-diverging fungi and yeasts, but collaborates with other faculty to study these same questions in other regulatory systems (e.g. circadian clocks) and organisms (e.g. animals and plants).
Buchler received a Bachelor of Science in physics from the University of California, San Diego, before working on protein structure and evolution while obtaining a Ph.D. in biophysics at the University of Michigan at Ann Arbor. During his postdoctoral research appointments, first at the University of California at San Diego and then at the Center for Studies in Physics and Biology at Rockefeller University, he combined mathematical modeling and experiments to understand how networks of genes sense and respond to multiple signals, store memories of past events, and schedule periodic events (e.g. cell cycle).