Modeling the Living Embryo

Our research applies precision measurements of molecular, cellular and tissue dynamics in living embryos, along with computer simulation and modeling, to understand the development, growth and diversification of plants and animals.

About

Cluster Coordinator

Troy Ghashghaei (Molecular Biomedical Sciences)
Nanette Nascone-Yoder (Molecular Biomedical Sciences)*
*primary contact

Cluster Colleges

College of Agriculture and Life Sciences, College of Engineering, College of Sciences, College of Veterinary Medicine (Lead College)

NC State developmental biologists will recruit candidates whose research addresses four distinct knowledge gaps in developmental biology where forefront progress can be made through use of quantitative and computational approaches. These include: 1) How are individual cell fate decisions made – how does a specific embryonic or undifferentiated cell develop into a particular final cell type? 2) What is the influence of biomechanics on plant and animal morphogenesis? 3) What mechanisms underlie the organization of cell fates in space and time? 4) How do genetic and environmental variation interact with phenotypic plasticity and the evolution of new biological forms? New cluster faculty will have a home in one of the following departments: Molecular Biomedical Sciences, Plant and Microbial Biology, Biological Sciences, Mathematics, Chemical and Biological Engineering, or Biomedical Engineering.

Open Positions

Impact

stages of development of a plant and living embryos

Stages of development of a plant and living embryos.

A common goal for developmental biologists is to manipulate developmental processes and events for human benefit. Developmental research has revealed causes of birth defects, spawned the field of stem cell and regenerative biology, informed cancer biology and efforts to engineer artificial tissues and organs, and illuminated the plasticity of plant morphogenesis, responses to stress and the basis of crop yield and quality. However, it is becoming widely recognized that entirely new experimental and analytical approaches are necessary to understand the transition from egg to embryo, seed to plant. Identification of the factors that influence animal development, full-term birth and later adult-onset disease will have far reaching socio-economic and policy implications. Likewise in developing plants, mechanisms that control seed number, growth rate and organ identity and size under diverse environmental conditions are highly relevant to food, feed, fiber and fuel production. With our strengths in traditional biological, engineering, and quantitative and computational sciences, our cluster will set standards in quantitative and computational developmental biology.

History

At NC State, faculty in developmental biology have a common interest in applying quantitative and computational methods to understand complex problems in animal and plant development. Toward this goal, 49 faculty across 16 departments in the colleges of Veterinary Medicine, Agriculture and Life Sciences, Sciences and Engineering have joined forces to recruit four new faculty members. The aim is to build a dynamic group of interdisciplinary faculty who address important questions in developmental biology in various animal and plant models by combining cutting-edge experimental, quantitative and computational approaches.